Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production
Thioredoxin reductases are frequently overexpressed in various solid tumors as a protective mechanism against heightened oxidative stress.Inhibitors of this system, such as Auranofin, are effective in eradicating cancer cells.However, the clinical significance of thioredoxin reductase 1 (TrxR1) in lung travc cancer, as well as the potential for its